Learn how to dash in Rage 2, an ability that will help you to dodge enemies incoming projectiles, also with Dash ability you can confuse attacking enemies in Rage 2.
Learn how to use Overdrive in Rage 2, how to refill Overdrive and its benefit. Overdrive will restore health, amplify damage and enemies killed will drop better loots.
In Rage 2 you will lose health in battle, and you can regain health by collecting an item dropped by enemies, read How to Gain Health In Rage 2 for details.